Abstract
Dendronized poly(amido amine)s (DPs) bearing tri-phosphate or bis-phosphonate peripheral groups are synthesized. These worm-like DPs can template the formation of BMSCs adhesive hydroxylapatite (HA) on the nano-scale, or self-assemble into mineral-collecting microfibers on the micro-scale, exhibiting similar functions of non-collagenous proteins (NCPs) in the natural biomineralization process of HA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bone Marrow Cells / cytology
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Cell Adhesion / drug effects
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Cell Proliferation / drug effects
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Dendrimers / chemistry*
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Durapatite / chemistry*
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Durapatite / pharmacology
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Humans
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Mesenchymal Stem Cells / cytology
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Nanoparticles / chemistry
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Phosphorylation
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Polyamines / chemistry*
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Proteins / chemistry
Substances
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Dendrimers
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Poly(amidoamine)
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Polyamines
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Proteins
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Durapatite