Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report

Int J Clin Exp Pathol. 2014 Mar 15;7(4):1800-4. eCollection 2014.

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).

Keywords: Mantle; lymphoma; therapy; transformation; variant.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 4 / genetics*
  • Cyclin D1 / genetics
  • DNA-Binding Proteins / genetics*
  • Drug Therapy
  • Drug-Related Side Effects and Adverse Reactions / complications
  • Gene Rearrangement
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Lymphoma, Mantle-Cell / drug therapy*
  • Male
  • Middle Aged
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Nuclear Proteins / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Transcriptional Elongation Factors
  • Translocation, Genetic / genetics*
  • Treatment Outcome

Substances

  • DNA-Binding Proteins
  • Immunoglobulin Heavy Chains
  • KMT2A protein, human
  • Nuclear Proteins
  • Transcriptional Elongation Factors
  • Cyclin D1
  • Myeloid-Lymphoid Leukemia Protein
  • AFF1 protein, human
  • Histone-Lysine N-Methyltransferase