[Clinical study of the vulvar Paget's disease: report of 8 cases]

Nihon Gan Chiryo Gakkai Shi. 1989 Dec 20;24(11):2563-8.
[Article in Japanese]

Abstract

Between 1949 and 1987, 8 cases of the vulvar Paget's disease were treated at the Cancer Institute Hospital. These cases constituted 9.5% of the total number of the vulvar malignancies at our hospital during the same period. The clinicopathological findings were described. The average age was 73.3 years. The most frequent symptom was vulvar eczematous change with itching, which was seen in 7 cases (87.5%). About 5 years was required from onset of the disease until diagnosis. Vulvar cytologic examination revealed positive for cancer in 5 out of 8 cases (62.5%). One patient developed squamous cell carcinoma of the face. All patients underwent operation. Two patients had preoperative adjuvant chemotherapy by Bleomycin which was not effective histologically. Five patients had a underlying invasive tumor (62.5%) at initial therapy. The 5-year survival rate was 50.0%. Prognosis of the vulvar Paget's disease appears to be poor.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bleomycin / therapeutic use
  • Female
  • Humans
  • Paget Disease, Extramammary / pathology*
  • Paget Disease, Extramammary / therapy
  • Prognosis
  • Vulvar Neoplasms / pathology*
  • Vulvar Neoplasms / therapy

Substances

  • Bleomycin