5-Prenyltryptophol, a new inhibitor of bone morphogenetic protein-induced alkaline phosphatase expression in myoblasts, produced by Streptomyces colinus subsp. albescens HEK608

J Antibiot (Tokyo). 2014 Aug;67(8):589-91. doi: 10.1038/ja.2014.44. Epub 2014 May 14.

Authors

Ryuji Uchida¹, Megumi Nakai¹, Satoshi Ohte², Hiroyasu Onaka³, Takenobu Katagiri², Hiroshi Tomoda¹

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
² Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.
³ Faculty of Engineering, Department of Biotechnology, Toyama Prefectural University, Imizu-shi, Toyama, Japan.

PMID: 24824820
DOI: 10.1038/ja.2014.44

No abstract available

MeSH terms

Activin Receptors, Type I / antagonists & inhibitors
Activin Receptors, Type I / genetics
Activin Receptors, Type I / metabolism*
Animals
Bone Morphogenetic Proteins / pharmacology*
Cell Line
Gene Expression Regulation, Enzymologic / drug effects*
Indoles / chemistry
Indoles / metabolism
Indoles / pharmacology*
Mice
Molecular Structure
Myoblasts / drug effects*
Myoblasts / metabolism
Streptomyces / classification
Streptomyces / genetics
Streptomyces / metabolism*

Substances

5-prenyltryptophol
Bone Morphogenetic Proteins
Indoles
ACVR1 protein, human
Activin Receptors, Type I