A Pd-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization: a new entry to 2-amino-phenols

Org Biomol Chem. 2014 Jun 28;12(24):4084-8. doi: 10.1039/c4ob00652f.

Abstract

A palladium-catalyzed cascade reaction of N-H insertion (NHI) and oxidative dehydrogenative aromatization (ODA) has been developed, which affords a straightforward and efficient way to access the carbazole precursors (2-arylamino-phenols) as well as to prepare 2-alkylamino-phenols from non-aromatic substrates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis
  • Alkaloids / chemistry
  • Aminophenols / chemistry*
  • Catalysis
  • Hydrocarbons, Aromatic / chemistry*
  • Hydrogenation
  • Oxidation-Reduction
  • Palladium / chemistry*

Substances

  • Alkaloids
  • Aminophenols
  • Hydrocarbons, Aromatic
  • 2-aminophenol
  • Palladium