Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia

Intern Med. 2014;53(10):1087-91. doi: 10.2169/internalmedicine.53.1366.

Abstract

Zygomycosis is a lethal and invasive mold infection that is often associated with hematological malignancies. The keys for successful treatment include making a rapid diagnosis and appropriately administering antifungal agents. We herein report the early diagnosis of a case of zygomycosis in a patient with acute myeloid leukemia using a deoxyribonucleic acid sequence analysis. We successfully performed allogeneic hematopoietic stem cell transplantation with the use of high-dose liposomal amphotericin B and granulocyte transfusion.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Liposomes
  • Male
  • Middle Aged
  • Mucormycosis / complications
  • Mucormycosis / diagnosis*
  • Mucormycosis / drug therapy*
  • Opportunistic Infections / complications
  • Opportunistic Infections / diagnosis*
  • Opportunistic Infections / drug therapy*
  • Polymerase Chain Reaction
  • Rhizomucor / genetics*
  • Rhizomucor / isolation & purification
  • Sequence Analysis, DNA*

Substances

  • Antifungal Agents
  • Liposomes
  • liposomal amphotericin B
  • Granulocyte Colony-Stimulating Factor
  • Amphotericin B