Abstract
Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocked carrageenan-induced hyperalgesia, hyperthermia and edema. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.
MeSH terms
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Analgesics / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal
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Aprotinin / pharmacology
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Bradykinin / analogs & derivatives*
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Bradykinin / antagonists & inhibitors*
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Bradykinin / biosynthesis
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Bradykinin / pharmacology
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control*
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Fever / chemically induced
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Fever / prevention & control*
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Kallikreins / antagonists & inhibitors
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Male
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Pain / chemically induced
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Pain / prevention & control*
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Rats
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Rats, Inbred Strains
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Carrageenan
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Aprotinin
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NPC 567
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Kallikreins
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Bradykinin