Quinoid glycosides from Forsythia suspensa

Phytochemistry. 2014 Aug:104:105-13. doi: 10.1016/j.phytochem.2014.04.010. Epub 2014 May 12.

Abstract

Phytochemical investigation on Forsythia suspensa (Thunb.) Vahl afforded 10 compounds, including quinoid glycosides, lignan glycosides, phenylethanoid glycoside and allylbenzene glycoside together with 13 known ones. Their structures were established based on extensive spectroscopic data analyses, including IR, UV, HRESIMS, 1D NMR and 2D NMR. Absolute configurations were determined by ECD calculation method and chemical degradation. In addition, all compounds were evaluated for their antiviral activity against influenza A (H1N1) virus and several were further evaluated against respiratory syncytial virus (RSV) in vitro. Among them, two previously known compounds showed significant activities against RSV with EC50 values of 3.43 and 6.72 μM.

Keywords: Antiviral activity; Forsythia suspensa; Lignan glycosides; Quinoid glycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Dogs
  • Forsythia / chemistry*
  • Fruit / chemistry
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Lignans / chemistry
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phenylethyl Alcohol / chemistry
  • Phenylethyl Alcohol / isolation & purification
  • Phenylethyl Alcohol / pharmacology*
  • Respiratory Syncytial Viruses / drug effects

Substances

  • Antiviral Agents
  • Glycosides
  • Lignans
  • Phenylethyl Alcohol