Abstract
Seven new polyketides, for which the trivial names hyafurones A1-B (1-3), hyapyrrolines A (4) and B (5), and hyapyrones A (6) and B (7) are proposed, were isolated from the fermentation broth of the myxobacteria Hyalangium minutum, strains NOCB-2(T) and Hym-3. Their structures were elucidated from NMR and HRESIMS data, and their geometric configuration was assigned based on NOE and vicinal (1)H coupling data. Both hyafurone B (3) and hyapyrone B (7) inhibited growth of the Gram-positive bacterium Nocardia flava, while 7 showed antifungal activity against Mucor hiemalis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Myxococcales / chemistry*
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Nocardia / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology
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Pyrans / chemistry
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Pyrans / isolation & purification*
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Pyrans / pharmacology
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology
Substances
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Antifungal Agents
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Furans
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Polyketides
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Pyrans
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Pyrroles