Synthesis of isatins by I2/TBHP mediated oxidation of indoles

Org Lett. 2014 Jun 6;16(11):3094-7. doi: 10.1021/ol501203q. Epub 2014 May 21.

Authors

You Zi¹, Zhong-Jian Cai, Shun-Yi Wang, Shun-Jun Ji

Affiliation

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou 215123, China.

PMID: 24850466
DOI: 10.1021/ol501203q

Abstract

An I2/TBHP mediated oxidation of commercially available indoles has been developed, which affords isatins in moderate to good yields.