Focusing in on T cell cross-reactivity

Judith N Mandl; Ronald N Germain

doi:10.1016/j.cell.2014.05.002

Focusing in on T cell cross-reactivity

Cell. 2014 May 22;157(5):1006-8. doi: 10.1016/j.cell.2014.05.002.

Authors

Judith N Mandl¹, Ronald N Germain²

Affiliations

¹ Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: [email protected].
² Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: [email protected].

PMID: 24855938
DOI: 10.1016/j.cell.2014.05.002

Abstract

To provide broad immunity to a vast array of foreign antigens with a limited number of T lymphocytes, each cell has to recognize many targets. By implementing a strategy to identify T cell receptor (TCR) ligands and investigating at a fine granularity their structure and sequence relationship, Birnbaum et al. demonstrate the surprisingly tight focus of such T cell cross-reactivity.

Publication types

Comment

MeSH terms

Animals
Humans
Peptides / chemistry*
Receptors, Antigen, T-Cell / chemistry*
T-Lymphocytes / immunology*

Substances

Peptides
Receptors, Antigen, T-Cell