Distinct age-matched serum biomarker profiles in patients with cutaneous T-cell lymphoma

Exp Dermatol. 2014 Aug;23(8):598-600. doi: 10.1111/exd.12455. Epub 2014 Jul 16.

Abstract

Immunological functions decline with age. Because MS/SzS predominately affects the elderly, it is important to distinguish age-related from cancer-specific changes. Also, MF and SzS are malignancies of CD4(+) T-lymphocytes, further compromising an immune state of the patients. The objectives of this study were to distinguish disease-specific immunological deterioration by performing comparative age-matched Luminex multiplex assessment of 34 serum biomarkers between patients with MF/SzS, HIV-infected individuals and normal controls. Controlling for age, expression level appears to significantly differ between patients with MF/SzS and controls for the following biomarkers: G-CSF, IL-5, MIP-1β, TNF-α, VEGF, EOTAXIN, IL-8, IL-12, IL-2R, IP10, MCP-1, MIG, TNFR1 and TNFR2 (P < 0.05), while others showed normal age-related changes. Interestingly, cluster analysis placed MF/SzS profiles closer to HIV. This further underscores an immunologically compromised state of patients with MF/SzS and suggests its potential self-perpetuating role in disease progression.

Keywords: age; biomarkers; cutaneous T-cell lymphoma; cytokines.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aging / blood*
  • Biomarkers / blood
  • Case-Control Studies
  • Chemokine CCL4 / blood*
  • Disease Progression
  • Granulocyte Colony-Stimulating Factor / blood*
  • HIV Infections / blood
  • Humans
  • Interleukin-5 / blood*
  • Mycosis Fungoides / blood
  • Sezary Syndrome / blood*
  • Sezary Syndrome / diagnosis
  • Skin Neoplasms / blood*
  • Skin Neoplasms / diagnosis

Substances

  • Biomarkers
  • Chemokine CCL4
  • Interleukin-5
  • Granulocyte Colony-Stimulating Factor