Material of the paederine genus Lathrobium Gravenhorst, 1802 from the Chinese provinces Heilongjiang, Ningxia, Qinghai, Henan, Anhui, Zhejiang, Jiangxi, Hunan, Chongqing, Guizhou, Yunnan and Guangdong was examined. Twenty-one species were identified, seventeen of which are described as new: L. liuae (Heilongjiang: Hongwei); L. ningxiaense sp. n. (Ningxia: Heshangpu); L. baiyunense sp. n. (Henan: Baiyun Shan); L. ayui sp. n. (Anhui: Yaoluoping); L. yaoluopingense sp. n. (Anhui: Yaoluoping); L. chenae sp. n. (Zhejiang: Qingliangfeng); L. fengae sp. n. (Zhejiang: Qingliangfeng); L. gutianense sp. n. (Zhejiang: Gutian Shan); L. nannani sp. n. (Zhejiang: Gutian Shan); L. sanqingense sp. n. (Jiangxi: Sanqing Shan); L. badagongense sp. n. (Hunan: Badagong Shan); L. xui sp. n. (Chongqing: Huanggangou); L. fanjingense sp. n. (Guizhou: Fanjing Shan); L. lui sp. n. (Guizhou: Kuankuoshui); L. zhaigei sp. n. (Guizhou: Kuankuoshui); L. zizhiense sp. n. (Yunnan: Zizhi) and L. guangdongense sp. n. (Guangdong: Nanling). The female sexual characters of L. lingae Peng, Li & Zhao and L. longwangshanense Peng, Li & Zhao are described and illustrated for the first time. The junior primary homonym Lathrobium pilosum Peng & Li, 2012 is replaced with Lathrobium zhui nom. n. Including the new taxa described here, 189 Lathrobium species are currently known from the mainland China.