Redox or death: checking on fetal myogenesis

Lucia Latella; Pier Lorenzo Puri

doi:10.1016/j.devcel.2014.05.005

Redox or death: checking on fetal myogenesis

Dev Cell. 2014 May 27;29(4):373-4. doi: 10.1016/j.devcel.2014.05.005.

Authors

Lucia Latella¹, Pier Lorenzo Puri²

Affiliations

¹ Laboratory of Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Institute of Translational Pharmacology, National Research Council of Italy, Via Fosso del Cavaliere 100, 00133 Rome, Italy. Electronic address: [email protected].
² Laboratory of Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Development Aging and Regeneration Program, Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: [email protected].

Abstract

Reporting in this issue of Developmental Cell, L'honoré et al. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.

Publication types

Comment

MeSH terms

Animals
Homeobox Protein PITX2
Homeodomain Proteins / genetics*
Nuclear Respiratory Factor 1 / genetics*
Reactive Oxygen Species / metabolism*
Transcription Factors / genetics*

Substances

Homeodomain Proteins
Nrf1 protein, mouse
Nuclear Respiratory Factor 1
Reactive Oxygen Species
Transcription Factors
homeobox protein PITX3

Abstract

Publication types

MeSH terms

Substances

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