Lifestyle factors in drug users may render them particularly vulnerable to HIV infection. This study examined a group of 74 registered drug users at a Drug Dependency Clinic and compared lifestyle factors in those who were HIV-positive and those HIV-negative. Despite HIV status, sharing was extensive (over 90%). Sharing with partners only is not fail-safe as partners in turn shared. Sexual behaviour within this group may exacerbate risk. A number of subjects reported previous Sexually Transmitted Diseases which may in themselves indicate high levels of sexual activity and act as co-factors for virus spread. Soliciting for sex was reported present among the positives and negatives. Condom use for primary or prophylactic protection was rarely undertaken. There were no differences between HIV-positive and HIV-negative respondents indicating the high level of risk faced by the group as a whole. This presents a challenge for the provision of adequate and appropriate health advice and care.