Association between urine aldosterone and diastolic function in patients with primary aldosteronism and essential hypertension

Clin Biochem. 2014 Sep;47(13-14):1329-32. doi: 10.1016/j.clinbiochem.2014.05.062. Epub 2014 Jun 2.

Abstract

Objective: To investigate the association between aldosterone and cardiac diastolic dysfunction.

Design and methods: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed.

Results: PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function.

Conclusions: Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.

Keywords: Diastolic dysfunction; Primary aldosteronism; Urine aldosterone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aldosterone / blood
  • Aldosterone / urine*
  • Echocardiography / methods
  • Essential Hypertension
  • Female
  • Humans
  • Hyperaldosteronism / blood
  • Hyperaldosteronism / physiopathology*
  • Hyperaldosteronism / urine*
  • Hypertension / blood
  • Hypertension / physiopathology*
  • Hypertension / urine*
  • Male
  • Middle Aged
  • Prospective Studies
  • Ventricular Dysfunction, Left / blood
  • Ventricular Dysfunction, Left / physiopathology
  • Ventricular Dysfunction, Left / urine
  • Ventricular Function, Left / physiology*

Substances

  • Aldosterone