Father-son chats: inheriting stress through sperm RNA

Upasna Sharma; Oliver J Rando

doi:10.1016/j.cmet.2014.05.015

Father-son chats: inheriting stress through sperm RNA

Cell Metab. 2014 Jun 3;19(6):894-5. doi: 10.1016/j.cmet.2014.05.015.

Authors

Upasna Sharma¹, Oliver J Rando²

Affiliations

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: [email protected].

Abstract

Although mounting evidence in mammals suggests that certain ancestral environmental exposures can influence the phenotype in future generations, mechanisms underlying such intergenerational information transfer remain unclear. A recent report suggests that RNA isolated from sperm can inform offspring of a father's history of early life trauma (Gapp et al., 2014).

Publication types

Comment

MeSH terms

Animals
Female
Male
MicroRNAs / metabolism*
Spermatozoa*
Stress, Psychological / etiology*
Stress, Psychological / therapy*

Substances

MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding