Abstract
A self-assembled nanoparticle containing a photosensitizer and a Trojan-horse moiety (cholesterol), binds an anti-TB pro-drug and increases 1000-fold its activity against mycobacteria. These minimalist constructs will allow development of economically viable, efficient drug preparations for the treatment of drug-resistant TB infections.
MeSH terms
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / pharmacology
-
Antitubercular Agents / chemistry*
-
Antitubercular Agents / pharmacology
-
Dose-Response Relationship, Drug
-
Mycobacterium fortuitum / drug effects*
-
Mycobacterium fortuitum / physiology
-
Nanoparticles / chemistry*
-
Photosensitizing Agents / chemistry
-
Photosensitizing Agents / pharmacology
-
Prodrugs / chemistry*
-
Prodrugs / pharmacology
Substances
-
Anti-Infective Agents
-
Antitubercular Agents
-
Photosensitizing Agents
-
Prodrugs