Abstract
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification*
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Benzopyrans / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Humans
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Structure
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Morus / chemistry*
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NF-kappa B / drug effects
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Plant Bark / chemistry
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Plant Roots / chemistry
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Prenylation
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Tumor Necrosis Factor-alpha / pharmacology
Substances
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Anti-Inflammatory Agents
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Benzofurans
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Benzopyrans
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Flavonoids
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Lipopolysaccharides
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NF-kappa B
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Tumor Necrosis Factor-alpha
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cudraflavone B
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morusinol