Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells

Leukemia. 2014 Oct;28(10):2101-4. doi: 10.1038/leu.2014.182. Epub 2014 Jun 6.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Coculture Techniques
  • Drug Resistance, Neoplasm
  • Humans
  • Inflammation
  • Integrin alpha4 / metabolism*
  • Leukemia / drug therapy
  • Mice
  • Neoplasm Transplantation
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Precursor Cells, B-Lymphoid / cytology
  • Precursor Cells, B-Lymphoid / drug effects*
  • Stromal Cells / cytology
  • Thiophenes / administration & dosage
  • Thiophenes / chemistry*
  • Urea / administration & dosage
  • Urea / analogs & derivatives*
  • Urea / chemistry

Substances

  • 3-(1,3-benzodioxol-5-yl)-3-((((-1-((bis(2-thienylmethyl)amino)carbonyl)pentyl)amino)carbonyl)amino)propanoic acid
  • Antineoplastic Agents
  • Thiophenes
  • Integrin alpha4
  • Urea