RIFAMPICIN: an antibiotic with brain protective function

Burak Yulug; Lütfü Hanoglu; Ertugrul Kilic; Wolf Rüdiger Schabitz

doi:10.1016/j.brainresbull.2014.05.007

RIFAMPICIN: an antibiotic with brain protective function

Brain Res Bull. 2014 Aug:107:37-42. doi: 10.1016/j.brainresbull.2014.05.007. Epub 2014 Jun 4.

Authors

Burak Yulug¹, Lütfü Hanoglu², Ertugrul Kilic³, Wolf Rüdiger Schabitz⁴

Affiliations

¹ Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey. Electronic address: [email protected].
² Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey.
³ Department of Physiology, Brain Research Laboratory, University of Istanbul-Medipol, Istanbul, Turkey.
⁴ Department of Neurology, Bethel-EvKB, Bielefeld, Germany.

PMID: 24905548
DOI: 10.1016/j.brainresbull.2014.05.007

Abstract

Besides its well known antibiotic activity rifampicin exerts multiple brain protective functions in acute cerebral ischemia and chronic neurodegeneration. The present mini-review gives an update of the unique activity of rifampicin in different diseases including Parkinson's disease, meningitis, stroke, Alzheimer's disease and optic nerve injury.

Keywords: Alzheimer's disease; Meningitis; Optic nerve injury; Parkinson's disease; Rifampicin; Stroke.

Publication types

Review

MeSH terms

Alzheimer Disease / drug therapy
Animals
Antibiotics, Antitubercular / therapeutic use*
Brain / metabolism*
Humans
Meningitis / drug therapy
Neuroprotective Agents / therapeutic use*
Optic Nerve Injuries / drug therapy
Parkinson Disease / drug therapy
Receptors, Glucocorticoid / metabolism
Rifampin / therapeutic use*
Stroke / drug therapy

Substances

Antibiotics, Antitubercular
Neuroprotective Agents
Receptors, Glucocorticoid
Rifampin