Targeting the Achilles' heel of drug-resistant cancer stem cells

Cell Cycle. 2014;13(13):2017-8. doi: 10.4161/cc.29460. Epub 2014 Jun 6.
No abstract available

Keywords: EGFR-TKI resistance; KRAS; NFkB; cancer stem cells; integrin β3.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Drug Resistance, Neoplasm*
  • ErbB Receptors / antagonists & inhibitors*
  • Female
  • Humans
  • Integrin beta3 / metabolism*
  • Lung Neoplasms / drug therapy*
  • Neoplastic Stem Cells / drug effects*
  • Protein Kinase Inhibitors / therapeutic use*
  • Proto-Oncogene Proteins / metabolism*
  • ral GTP-Binding Proteins / metabolism*
  • ras Proteins / metabolism*

Substances

  • Integrin beta3
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins
  • ErbB Receptors
  • ral GTP-Binding Proteins
  • ras Proteins