Sensitive and portable detection of telomerase activity in HeLa cells using the personal glucose meter

Xi Zhu; Huifeng Xu; Ruolan Lin; Guidi Yang; Zhenyu Lin; Guonan Chen

doi:10.1039/c4cc03553d

Sensitive and portable detection of telomerase activity in HeLa cells using the personal glucose meter

Chem Commun (Camb). 2014 Jul 25;50(58):7897-9. doi: 10.1039/c4cc03553d.

Authors

Xi Zhu¹, Huifeng Xu, Ruolan Lin, Guidi Yang, Zhenyu Lin, Guonan Chen

Affiliation

¹ College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China. [email protected] [email protected].

PMID: 24913096
DOI: 10.1039/c4cc03553d

Abstract

Using the personal glucose meter, a portable sensor was fabricated to assay telomerase activity and study the telomerase inhibitor AZT. Hence, it provided a promising approach for the detection of enzyme activity and diagnosis of cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / instrumentation*
Glucose
HeLa Cells
Humans
Telomerase / antagonists & inhibitors
Telomerase / metabolism*
Zidovudine / pharmacology

Substances

Zidovudine
Telomerase
Glucose