This study analyzes the relation of sexual orientation and gender to sexual sensation seeking. Participants were 382 individuals (200 men, 182 women) between 17 and 29 years old who completed the Sexual Sensation Seeking Scale. Of the 382 participants, 52.46% self-reported heterosexual orientation, and 47.64% self-reported homosexual orientation. The results showed differences with Sexual Sensation Seeking being more frequent among heterosexuals and men. There were no differences between heterosexual and homosexual men. Heterosexual women had higher sexual sensation seeking scores than did homosexual women. These results and their possible implications for the effective development of prevention and intervention programs in affective-sexual education are discussed.