An irradiance-mode absolute differential spectral response (SR) measurement system based on a light emitting diode (LED) array is described. The LEDs are coupled to an integrating sphere whose output irradiance is uniform to better than 2% over an area of 160 mm by 160 mm. SR measurements of solar cells when subject to diffuse irradiation, as provided by the integrating sphere, are compared with collimated irradiance SR measurements. Issues originating from the differences in angular response of the reference versus the test cells are also investigated. The SR curves of large-area cells with dimensions of up to 155 mm are measured and then used to calculate the cell's short circuit current (I(sc)), if illuminated by a defined solar spectrum. The resulting values of I(sc) agree well with the values obtained from secondary measurements.