Antigen smuggling in tuberculosis

Denis Hudrisier; Olivier Neyrolles

doi:10.1016/j.chom.2014.05.018

Antigen smuggling in tuberculosis

Cell Host Microbe. 2014 Jun 11;15(6):657-9. doi: 10.1016/j.chom.2014.05.018.

Authors

Denis Hudrisier¹, Olivier Neyrolles²

Affiliations

¹ CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne BP64182, 31077 Toulouse, France; Université de Toulouse, UPS, IPBS, 31077 Toulouse, France.
² CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne BP64182, 31077 Toulouse, France; Université de Toulouse, UPS, IPBS, 31077 Toulouse, France. Electronic address: [email protected].

PMID: 24922567
DOI: 10.1016/j.chom.2014.05.018

Abstract

The importance of CD4 T lymphocytes in immunity to M. tuberculosis is well established; however, how dendritic cells activate T cells in vivo remains obscure. In this issue of Cell Host & Microbe, Srivastava and Ernst (2014) report a mechanism of antigen transfer for efficient activation of antimycobacterial T cells.

Publication types

Comment

MeSH terms

Animals
Antigens, Bacterial / metabolism*
CD4-Positive T-Lymphocytes / microbiology*
Dendritic Cells / microbiology*
Mycobacterium tuberculosis / pathogenicity*

Substances

Antigens, Bacterial
Mycobacterium tuberculosis antigens