Abstract
Using a co-culture system of fractionated B cells and highly purified NK cells, we have demonstrated direct interactions between B lymphocytes and NK cells. B cells are able to stimulate the production of IFN-gamma by NK cells. This stimulatory ability is restricted to a subpopulation of large, presumably in vivo activated B lymphocytes. The secreted IFN-gamma in turn inhibits polyclonally induced B cell proliferation. Small resting B cells neither stimulate IFN-gamma production nor are they measurably affected by NK cells.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
B-Lymphocytes / immunology*
-
B-Lymphocytes / metabolism
-
Cell Line
-
Cytotoxicity, Immunologic
-
Female
-
Growth Inhibitors / pharmacology
-
Immune Sera / pharmacology
-
Immunoglobulins / biosynthesis
-
Immunosuppressive Agents / pharmacology
-
Interferon-gamma / biosynthesis
-
Interferon-gamma / immunology
-
Interferon-gamma / physiology*
-
Killer Cells, Natural / immunology*
-
Leukemia, Lymphocytic, Chronic, B-Cell / immunology
-
Lipopolysaccharides
-
Lymphocyte Activation / drug effects
-
Mice
-
Mice, Inbred BALB C
Substances
-
Growth Inhibitors
-
Immune Sera
-
Immunoglobulins
-
Immunosuppressive Agents
-
Lipopolysaccharides
-
Interferon-gamma