Abstract
Two new polyketides of the amphidinol family, amphidinol 18 (AM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae. Structure elucidation of the two polyoxygenated molecules has been accomplished by extensive use of spectroscopic and spectrometric techniques. AM18 exhibited antifungal activity against Candida albicans at 9 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects
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Dinoflagellida / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology*
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Pyrans / chemistry
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Sulfuric Acid Esters / chemistry
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Sulfuric Acid Esters / isolation & purification*
Substances
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Alkenes
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Antifungal Agents
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Polyketides
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Pyrans
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Sulfuric Acid Esters
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amphidinol 18
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amphidinol 19
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amphidinol 3