Abstract
2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.
Keywords:
Antivirals; HCV; RNA target; Translation inhibitor.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Benzoxazoles / chemical synthesis
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Benzoxazoles / chemistry
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Benzoxazoles / pharmacology*
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Hepacivirus / chemistry
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Hepacivirus / drug effects*
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Ligands
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Models, Molecular
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Molecular Structure
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RNA, Viral / antagonists & inhibitors*
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RNA, Viral / metabolism
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Ribosomes / drug effects*
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Ribosomes / metabolism
Substances
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Antiviral Agents
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Benzoxazoles
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Ligands
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RNA, Viral