Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties

J Antibiot (Tokyo). 1989 Jan;42(1):14-7. doi: 10.7164/antibiotics.42.14.

Abstract

Myxochelin A, a new catechole siderophore, was isolated from the culture broth of the myxobacterium, Angiococcus disciformis strain An d30. As is the case with other iron-chelating compounds the production of myxochelin A could be markedly increased up to 44 mg/liter by fermentation at low iron concentrations (10(-7) M FeCl3). The new substance showed weak activity against some bacteria.

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Iron Chelating Agents / isolation & purification*
  • Iron Chelating Agents / pharmacology
  • Lysine / analogs & derivatives*
  • Lysine / isolation & purification
  • Lysine / pharmacology
  • Microbial Sensitivity Tests
  • Myxococcales / metabolism*

Substances

  • Iron Chelating Agents
  • myxochelin A
  • Lysine