Cytotoxic compounds from the leaves of Garcinia polyantha

Alain Meli Lannang; Simplice J N Tatsimo; Hugues Fouotsa; Jean Paul Dzoyem; Ajit Kumar Saxena; Norbert Sewald

doi:10.1002/cbdv.201300401

Cytotoxic compounds from the leaves of Garcinia polyantha

Chem Biodivers. 2014 Jun;11(6):975-81. doi: 10.1002/cbdv.201300401.

Authors

Alain Meli Lannang¹, Simplice J N Tatsimo, Hugues Fouotsa, Jean Paul Dzoyem, Ajit Kumar Saxena, Norbert Sewald

Affiliation

¹ Department of Organic Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon, (phone: +237-77-534830; fax: +237-22-229116); Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld. [email protected].

PMID: 24934683
DOI: 10.1002/cbdv.201300401

Abstract

A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.

Keywords: Antiproliferative activity; Garcinia polyantha; Xanthones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Agents, Phytogenic / toxicity
Apoptosis / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Clusiaceae / chemistry*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HeLa Cells
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / isolation & purification
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Heterocyclic Compounds, 4 or More Rings / toxicity
Humans
Inhibitory Concentration 50
MCF-7 Cells
Molecular Structure
Plant Leaves / chemistry*
Structure-Activity Relationship
Xanthones / chemistry
Xanthones / isolation & purification
Xanthones / pharmacology*
Xanthones / toxicity

Substances

Antineoplastic Agents, Phytogenic
Heterocyclic Compounds, 4 or More Rings
Xanthones