Self-assemble ZnMn2O4 hierarchical hollow microspheres into self-supporting architecture for enhanced biosensing performance

Minggang Zhao; Bin Cai; Ye Ma; Hi Cai; Jingyun Huang; Xinhua Pan; Haiping He; Zhizhen Ye

doi:10.1016/j.bios.2014.05.051

Self-assemble ZnMn2O4 hierarchical hollow microspheres into self-supporting architecture for enhanced biosensing performance

Biosens Bioelectron. 2014 Nov 15:61:443-7. doi: 10.1016/j.bios.2014.05.051. Epub 2014 May 28.

Authors

Minggang Zhao¹, Bin Cai¹, Ye Ma¹, Hi Cai¹, Jingyun Huang², Xinhua Pan¹, Haiping He¹, Zhizhen Ye³

Affiliations

¹ Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.
² Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China; Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, China. Electronic address: [email protected].
³ Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China; Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, China. Electronic address: [email protected].

PMID: 24934745
DOI: 10.1016/j.bios.2014.05.051

Abstract

We demonstrate a facile and scalable approach to fabricate and self-assemble the hierarchical hollow microspheres into self-supporting architecture by naturally grown branches. The supporting branches can afford integrated transport channels and significantly improve the kinetic performance and mechanical stability. Meanwhile, the supported hierarchical microspheres acting as functional cell can provide high active sites, multiple response and suitable environment for immobilizing biomolecules. Different enzymes are immobilized for biosensors. The experiments demonstrate that the effective assembly of hierarchical microspheres into large size ordered architecture by self-supporting branches can significantly enhance the biosensing performance.

Keywords: Biosensor; Hierarchical structure; Hollow; Self-assemble; Self-supporting.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / instrumentation*
Electrochemical Techniques / instrumentation
Electrodes
Manganese Compounds / chemistry*
Microspheres
Oxides / chemistry*
Porosity
Zinc / chemistry*

Substances

Manganese Compounds
Oxides
manganese oxide
Zinc