Listeria exploits damage and death to spread bad news

Basel H Abuaita; Mary X O'Riordan

doi:10.1016/j.tim.2014.06.001

Listeria exploits damage and death to spread bad news

Trends Microbiol. 2014 Jul;22(7):370-1. doi: 10.1016/j.tim.2014.06.001. Epub 2014 Jun 13.

Authors

Basel H Abuaita¹, Mary X O'Riordan²

Affiliations

¹ Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
² Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

Abstract

Pathogenic Listeria monocytogenes replicates within the host cytosol; little is known about how it transits from cell to cell, spreading infection. A recent study implicates infection-induced membrane damage as a trigger for efferocytosis, the recognition and uptake of dead cells, thereby tricking neighboring cells into taking up the invader.

Keywords: Listeria; dissemination; efferocytosis; membrane damage.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cell Surface Extensions / microbiology*
Female
Humans
Listeria monocytogenes / physiology*
Phagocytosis*

Abstract

Publication types

MeSH terms

Grants and funding