Purpose: To compare the levels of MMP-8 and TIMP-1 in the gingival crevicular fluid (GCF)of chronic periodontitis(CP) patients before and after non-surgical periodontal therapy.
Methods: Sulcus bleeding index (SBI), plaque index (PLI) and probing depth (PD) were detected before and after therapy. GCF was collected from CP patients before and after therapy. MMP-8 and TIMP-1 were determined by enzyme-linked immunoabsorbent assay. The data was analyzed using paired-sample t test and multi-correlation analysis with SSPS 19.0 software package.
Results: The levels of MMP-8 and TIMP-1 decreased after therapy, and there was no significant difference in the MMP-8/TIMP-1 ratio. Correction analysis showed that a significant correction was found between MMP-8 and GCF weight.
Conclusions: MMP-8 and TIMP-1 decrease after non-surgical periodontal therapy.