First treatment of mycosis fungoides by total skin electron beam (TSEB) therapy in Greece

Stefanos Diamantopoulos; Kalliopi Platoni; Vassilis Kouloulias; Panayiotis Pantelakos; Maria Dilvoi; Evangelia Papadavid; Christina Antoniou; Efstathios Efstathopoulos

doi:10.1016/j.rpor.2013.07.006

First treatment of mycosis fungoides by total skin electron beam (TSEB) therapy in Greece

Rep Pract Oncol Radiother. 2013 Aug 13;19(2):114-9. doi: 10.1016/j.rpor.2013.07.006. eCollection 2014 Mar.

Authors

Stefanos Diamantopoulos¹, Kalliopi Platoni¹, Vassilis Kouloulias¹, Panayiotis Pantelakos¹, Maria Dilvoi¹, Evangelia Papadavid², Christina Antoniou³, Efstathios Efstathopoulos¹

Affiliations

¹ Radiation Therapy Unit, University General Hospital 'Attikon', Athens, Greece.
² Dermatology Department, University General Hospital 'Attikon', Athens, Greece.
³ Dermatology Department, Andreas Syggros Hospital, Athens, Greece.

Abstract

Background: Mycosis fungoides (MF), the most common subtype of cutaneous T-Cell Lymphoma (CTCL), is a rare chronic skin neoplasia. Total skin electron irradiation has been employed along with a variety of other topical or systemic treatments for MF management.

Aim: To report the first case treated by TSEB irradiation protocol in Greece.

Materials and methods: A fractionated 36 Gy total skin electron beam (TSEB) therapy was prescribed to a 65-years-old male patient with mycosis fungoides (MF), stage IIB, refractory to several treatments during a 20-year period. Dose uniform delivery was monitored by thermo-luminescence dosimetry.

Results and discussion: The homogeneous skin dose distribution resulted in a complete clinical response. Limited, irradiation-oriented, side effects appeared.

Conclusions: The first TSEB irradiation prescription in Greek medical chronicles was proved effective in this case of tumor stage MF (T3-IIB), which had been refractory to several single or combination treatments.

Keywords: Mycosis fungoides; Radiation therapy; TSEB.