Abstract
A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Boron Compounds / chemistry*
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Diagnostic Imaging
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Humans
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Hypochlorous Acid / analysis*
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Hypochlorous Acid / chemistry
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Macrophages / metabolism
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Mice
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Molecular Structure
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Fluorescent Dyes
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Hypochlorous Acid