Cluster of Escherichia coli isolates producing a plasmid-mediated OXA-48 β-lactamase in a Spanish hospital in 2012

J Clin Microbiol. 2014 Sep;52(9):3414-7. doi: 10.1128/JCM.01271-14. Epub 2014 Jun 20.

Abstract

Three unrelated sequence type 131 (ST131), ST58, and ST83 Escherichia coli isolates with low-level resistance to imipenem and resistance to ertapenem were recovered in a Spanish hospital from July to October 2012. They were positive for blaOXA-48 carried by an IncL/M conjugative plasmid, which may have been acquired from Klebsiella pneumoniae.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Conjugation, Genetic
  • Ertapenem
  • Escherichia coli / classification
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Proteins
  • Female
  • Gene Transfer, Horizontal
  • Genotype
  • Hospitals
  • Humans
  • Imipenem / pharmacology
  • Male
  • Middle Aged
  • Plasmids / analysis
  • Spain / epidemiology
  • beta-Lactamases / genetics*
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • beta-Lactams
  • Imipenem
  • beta-Lactamases
  • beta-lactamase OXA-48, E coli
  • oxacillinase
  • Ertapenem