[3+3] annulation of allylic phosphoryl-stabilized carbanions/phosphorus ylides and vinyl azides: a practice strategy for synthesis of polyfunctionalized anilines

Chem Commun (Camb). 2014 Aug 11;50(62):8539-42. doi: 10.1039/c4cc03462g.

Abstract

Tandem Michael addition and Witting or Horner-Wadsworth-Emmons olefination initiated [3+3] annulation between vinyl azides and allylic phosphorus ylides or allylic phosphoryl-stabilized carbanions has been developed. This one-pot protocol furnishes highly functionalized anilines in good to excellent yields under mild, room-temperature conditions. A rational mechanism is also proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Aniline Compounds / chemical synthesis*
  • Aniline Compounds / chemistry
  • Anions / chemistry*
  • Azides / chemistry*
  • Crystallography, X-Ray
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular

Substances

  • Alkenes
  • Aniline Compounds
  • Anions
  • Azides