Abstract
Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation. More than seven decades later we know that these mechanisms include histone tail post-translational modifications, DNA methylation, ATP-dependent chromatin remodeling, and non-coding RNA pathways. Epigenetic modifications are powerful drugs targets, and combined targeting of multiple pathways is expected to significantly advance cancer therapy.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Chromatin / chemistry
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Chromatin / metabolism
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Chromatin Assembly and Disassembly
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DNA Methylation
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Epigenesis, Genetic*
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Histones / genetics
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Histones / metabolism*
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Humans
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Protein Binding
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Protein Multimerization
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Protein Processing, Post-Translational*
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RNA, Untranslated / genetics
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RNA, Untranslated / metabolism
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Receptors, Retinoic Acid / genetics
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Receptors, Retinoic Acid / metabolism*
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Retinoid X Receptors / genetics
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Retinoid X Receptors / metabolism*
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Signal Transduction
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Tretinoin / metabolism*
Substances
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Chromatin
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Histones
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RNA, Untranslated
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Tretinoin