Diversity of Francisella tularensis subsp. holarctica lineages, China

Emerg Infect Dis. 2014 Jul;20(7):1191-4. doi: 10.3201/eid2007.130931.

Abstract

We analyzed 10 isolates of Francisella tularensis subspecies holarctica from China and assigned them to known clades by using canonical single-nucleotide polymorphisms. We found 4 diverse subtypes, including 3 from the most basal lineage, biovar japonica. This result indicates unprecedented levels of diversity from a single region and suggests new models for emergence.

Keywords: China; Francisella tularensis subsp. holarctica; SNP; bacteria; canSNP; lineage; phylogeography; tularemia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • China
  • Francisella tularensis / genetics*
  • Humans
  • Phylogeny
  • Phylogeography / methods
  • Polymorphism, Single Nucleotide / genetics
  • Tularemia / microbiology