Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

Cunxiang Su; Ying Xie; Hongjie Pan; Mao Liu; Hua Tian; Yian Shi

doi:10.1039/c4ob00684d

Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

Org Biomol Chem. 2014 Aug 21;12(31):5856-60. doi: 10.1039/c4ob00684d.

Authors

Cunxiang Su¹, Ying Xie, Hongjie Pan, Mao Liu, Hua Tian, Yian Shi

Affiliation

¹ Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 10090, China.

PMID: 24969075
DOI: 10.1039/c4ob00684d

Abstract

This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Biomimetics*
Catalysis
Chemistry, Organic / methods*
Esters / chemical synthesis*
Esters / chemistry*
Stereoisomerism

Substances

Esters