Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells

Chao-Ying Cheng; Yan-Yan Feng; Yi Zang; Jia Li; Xiao-Peng He; Guo-Rong Chen

doi:10.1016/j.carres.2014.05.014

Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells

Carbohydr Res. 2014 Jul 23:394:39-42. doi: 10.1016/j.carres.2014.05.014. Epub 2014 May 29.

Authors

Chao-Ying Cheng¹, Yan-Yan Feng¹, Yi Zang², Jia Li³, Xiao-Peng He⁴, Guo-Rong Chen¹

Affiliations

¹ Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China.
² National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China. Electronic address: [email protected].
³ Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
⁴ Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China. Electronic address: [email protected].

PMID: 24972313
DOI: 10.1016/j.carres.2014.05.014

Abstract

A bis-triazolyl phenylalaninyl galactoside was synthesized by a two-fold click reaction between an azido phenylalanine and a di-O-propynyl galactoside. By a cytotoxicity assay the compound was determined to be selectively toxic for multiple myeloma (MM) among a series of cancer cell lines with no toxicity to a control cell line. A Western blot analysis suggested that this compound could potentiate the cleavage of poly ADP-ribose polymerase in MM cells, leading to apoptosis.

Keywords: Amino acid; Click chemistry; Cytotoxicity; Multiple myeloma; Sugar.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Line, Tumor / drug effects
Click Chemistry
Drug Screening Assays, Antitumor
Glycosides / chemistry
Humans
Multiple Myeloma / drug therapy*
Multiple Myeloma / pathology
Poly(ADP-ribose) Polymerases / metabolism

Substances

Antineoplastic Agents
Glycosides
Poly(ADP-ribose) Polymerases