NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

Dalton Trans. 2014 Aug 28;43(32):12150-5. doi: 10.1039/c4dt01356e.

Abstract

We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Cycle / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dimethyl Sulfoxide / analogs & derivatives*
  • Dimethyl Sulfoxide / pharmacology
  • Humans
  • Intermediate-Conductance Calcium-Activated Potassium Channels / antagonists & inhibitors*
  • Leukemia
  • Organometallic Compounds / pharmacology*
  • Potassium Channel Blockers / pharmacology*
  • Ruthenium Compounds

Substances

  • Antineoplastic Agents
  • Intermediate-Conductance Calcium-Activated Potassium Channels
  • KCNN4 protein, human
  • Organometallic Compounds
  • Potassium Channel Blockers
  • Ruthenium Compounds
  • imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)
  • Dimethyl Sulfoxide