Genome-wide identification of CRISPR/Cas9 off-targets in human genome

Cell Res. 2014 Aug;24(8):1009-12. doi: 10.1038/cr.2014.87. Epub 2014 Jul 1.

Authors

Jinzhi Duan¹, Guangqing Lu¹, Zhan Xie², Mingliang Lou², Jiao Luo², Lei Guo², Yu Zhang¹

Affiliations

¹ 1] Graduate Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China [2] National Institute of Biological Sciences, Beijing 102206, China.
² National Institute of Biological Sciences, Beijing 102206, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CRISPR-Associated Proteins / chemistry
CRISPR-Associated Proteins / genetics
CRISPR-Associated Proteins / metabolism*
Genome, Human*
HEK293 Cells
Homeodomain Proteins / genetics
Homeodomain Proteins / metabolism
Humans
Protein Structure, Tertiary
RNA / genetics
RNA / metabolism
Recombinant Fusion Proteins / biosynthesis
Recombinant Fusion Proteins / chemistry
Recombinant Fusion Proteins / genetics
Transcription Factors / genetics
Transcription Factors / metabolism

Substances

CRISPR-Associated Proteins
Homeodomain Proteins
Recombinant Fusion Proteins
Transcription Factors
empty spiracles homeobox proteins
RNA