NDM-5 carbapenemase-encoding gene in multidrug-resistant clinical isolates of Escherichia coli from Algeria

Antimicrob Agents Chemother. 2014 Sep;58(9):5606-8. doi: 10.1128/AAC.02818-13. Epub 2014 Jun 30.

Abstract

Here, we report the first autochthonous cases of infections caused by blaNDM-5 New Delhi metallo-β-lactamase-producing Escherichia coli strains recovered from urine and blood specimens of three patients from Algeria between January 2012 and February 2013. The three isolates belong to sequence type 2659 and they coexpress blaCTX-M-15 with the blaTEM-1 and blaaadA2 genes.

MeSH terms

  • Aged
  • Algeria
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics*
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / drug therapy*
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Sequence Data
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-lactamase CTX-M-15
  • beta-Lactamases
  • beta-lactamase NDM-1
  • beta-lactamase TEM-1
  • carbapenemase

Associated data

  • GENBANK/KF408072
  • GENBANK/KF408073
  • GENBANK/KF408074