The impact of symptom dimensions on outcome for exposure and ritual prevention therapy in obsessive-compulsive disorder

J Anxiety Disord. 2014 Aug;28(6):553-8. doi: 10.1016/j.janxdis.2014.06.001. Epub 2014 Jun 14.

Abstract

Objective: Obsessive-compulsive disorder (OCD) is a severe condition with varied symptom presentations. The behavioral treatment with the most empirical support is exposure and ritual prevention (EX/RP). This study examined the impact of symptom dimensions on EX/RP outcomes in OCD patients.

Method: The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used to determine primary symptoms for each participant. An exploratory factor analysis (EFA) of 238 patients identified five dimensions: contamination/cleaning, doubts about harm/checking, hoarding, symmetry/ordering, and unacceptable/taboo thoughts (including religious/moral and somatic obsessions among others). A linear regression was conducted on those who had received EX/RP (n=87) to examine whether scores on the five symptom dimensions predicted post-treatment Y-BOCS scores, accounting for pre-treatment Y-BOCS scores.

Results: The average reduction in Y-BOCS score was 43.0%, however the regression indicated that unacceptable/taboo thoughts (β=.27, p=.02) and hoarding dimensions (β=.23, p=.04) were associated with significantly poorer EX/RP treatment outcomes. Specifically, patients endorsing religious/moral obsessions, somatic concerns, and hoarding obsessions showed significantly smaller reductions in Y-BOCS severity scores.

Conclusions: EX/RP was effective for all symptom dimensions, however it was less effective for unacceptable/taboo thoughts and hoarding than for other dimensions. Clinical implications and directions for research are discussed.

Keywords: Exposure and response prevention; Factor analysis; Hoarding; Obsessive-compulsive disorder; Symptom dimensions; Treatment outcome.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Ceremonial Behavior
  • Cognitive Behavioral Therapy / methods*
  • Combined Modality Therapy
  • Factor Analysis, Statistical
  • Female
  • Hoarding Disorder
  • Humans
  • Implosive Therapy / methods*
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / prevention & control*
  • Obsessive-Compulsive Disorder / psychology
  • Psychiatric Status Rating Scales
  • Randomized Controlled Trials as Topic
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Thinking
  • Treatment Outcome
  • Young Adult

Substances

  • Serotonin Uptake Inhibitors