Too little mTORC1 activity injures the liver

Robert T Abraham

doi:10.1016/j.cmet.2014.06.005

Too little mTORC1 activity injures the liver

Cell Metab. 2014 Jul 1;20(1):4-6. doi: 10.1016/j.cmet.2014.06.005.

Author

Robert T Abraham¹

Affiliation

¹ Oncology Research Unit, Pfizer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121, USA. Electronic address: [email protected].

PMID: 24988455
DOI: 10.1016/j.cmet.2014.06.005

Abstract

Obesity promotes chronic activation of mTORC1 and is a known risk factor for hepatic injury, inflammation, and carcinogenesis. In this issue, Umemura et al. (2014) demonstrate that a persistent reduction in hepatic mTORC1 activity also promotes cell damage and inflammation and sensitizes the liver to cancer development.

Publication types

Comment

MeSH terms

Animals
Humans
Inflammation*
Liver / drug effects*
Male
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes / metabolism*
Sirolimus / toxicity*
TOR Serine-Threonine Kinases / metabolism*

Substances

Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases
Sirolimus