Four cases of vulvar cancer during the four years from 1979 to 1983 were examined at Saitama Medical School. Radical vulvectomy was performed for three cases and radiation therapy was undertaken for another one in stage IV. 1) Lymph node metastasis was histologically recognized in one of the three cases after radical vulvectomy. The depth of stromal invasion in the case with lymph node metastasis was 8 mm and the others were 1 mm and 6 mm. 2) IAP, SCC, CEA, CA125 and ferritin were examined in the four cases. SCC, CEA, CA125 and ferritin values were within normal range in all cases, but IAP values elevated over the normal range in two. 3) Ultrastructurally, we observed vulvar cancer calls before and after administration of UFT or CDDP. The results suggested that UFT and CDDP are effective against vulvar cancer.