Dynamic CT perfusion imaging of the myocardium using a wide-detector scanner: a semiquantitative analysis in an animal model

Daniela Muenzel; Peter B Noël; Bettina M Gramer; Vivian Leber; Armin Schneider; Alexander Leber; Mani Vembar; Alexander A Fingerle; Ernst J Rummeny; Armin Huber

doi:10.1016/j.clinimag.2014.05.011

Dynamic CT perfusion imaging of the myocardium using a wide-detector scanner: a semiquantitative analysis in an animal model

Clin Imaging. 2014 Sep-Oct;38(5):675-80. doi: 10.1016/j.clinimag.2014.05.011. Epub 2014 Jun 2.

Authors

Affiliations

¹ Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany. Electronic address: [email protected].
² Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
³ MITI - Minimal-Invasive Interdisciplinary Therapeutic Intervention Research Group, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
⁴ Heart Center Munich, Klinikum Bogenhausen, Englschalkinger Strasse 77, 81925 München, Germany.
⁵ Philips Healthcare, CT Clinical Science, 595 Miner Road, Cleveland, OH 44143, USA.

PMID: 24993639
DOI: 10.1016/j.clinimag.2014.05.011

Abstract

Background: Functional assessment of myocardial perfusion in computed tomography (CT) is a challenge.

Objective: To evaluate CT dynamic myocardial perfusion imaging (MPI) using a wide-detector scanner.

Methods: Time to peak (TTP), peak enhancement (PE), upslope (US), and the area under the curve (AUC) were calculated in 12 pigs (256-slice multidetector CT scanner).

Results: The entire myocardium was covered by the scan volume. TTP was increased, and PE, US, and AUC were decreased in poststenotic myocardium.

Conclusion: CT MPI with complete coverage of the myocardium is feasible, providing evaluation of the physiological significance of coronary artery stenosis.

Keywords: 256-Slice MDCT; Computed tomography; Coronary artery disease (CAD); Dynamic Myocardial perfusion; Ischemia.

MeSH terms

Animals
Coronary Circulation / physiology*
Equipment Design
Female
Multidetector Computed Tomography / instrumentation*
Myocardial Ischemia / diagnostic imaging*
Myocardial Ischemia / physiopathology
Myocardial Perfusion Imaging / methods*
Reproducibility of Results
Swine