DOT1L-HES6 fusion drives androgen independent growth in prostate cancer

EMBO Mol Med. 2014 Sep;6(9):1121-3. doi: 10.15252/emmm.201404210.

Authors

Matti Annala¹, Kati Kivinummi², Katri Leinonen², Joonas Tuominen², Wei Zhang³, Tapio Visakorpi², Matti Nykter²

Affiliations

¹ Institute of Biosciences and Medical Technology, Tampere, Finland Department of Signal Processing, Tampere University of Technology, Tampere, Finland.
² Institute of Biosciences and Medical Technology, Tampere, Finland.
³ Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism
Basic Helix-Loop-Helix Transcription Factors / physiology*
Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Rearrangement
Histone-Lysine N-Methyltransferase
Humans
Male
Methyltransferases / genetics
Methyltransferases / metabolism
Methyltransferases / physiology*
Middle Aged
Mutant Chimeric Proteins / genetics
Mutant Chimeric Proteins / metabolism
Mutant Chimeric Proteins / physiology*
Prostatic Neoplasms / metabolism*
Prostatic Neoplasms / pathology
Prostatic Neoplasms / surgery
Repressor Proteins / genetics
Repressor Proteins / metabolism
Repressor Proteins / physiology*
Sequence Analysis, DNA

Substances

Basic Helix-Loop-Helix Transcription Factors
HES6 protein, human
Mutant Chimeric Proteins
Repressor Proteins
DOT1L protein, human
Methyltransferases
Histone-Lysine N-Methyltransferase

Grants and funding